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Related Experiment Video

Updated: Jul 19, 2025

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A method for chronic and semi-chronic microelectrode array implantation in deep brain structures using image guided

Borna Mahmoudian1, Hitarth Dalal1, Jonathan Lau2

  • 1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Robarts Research Institute and Brain and Mind Institute, University of Western Ontario, 1151 Richmond St. N., London, ON N6A 5B7, Canada.

Journal of Neuroscience Methods
|August 12, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a novel method using custom cranial caps and 3D-printed microdrives for precise targeting of deep brain structures in monkeys. This technique improves accuracy and reduces infection risk for in-vivo electrophysiological recordings.

Keywords:
Deep brain structuresElectrophysiologyImage guided neuronavigationMicroelectrode implantationNon-human primatesStereoelectroencephalography (SEEG)

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Area of Science:

  • Neuroscience
  • Surgical techniques
  • Biomedical engineering

Background:

  • Accurate targeting of deep brain structures is crucial for neuroscience research but lacks established protocols.
  • Current methods often overlook individual anatomical variations, leading to inaccuracies.
  • Existing techniques for deep brain access can be invasive and infection-prone.

Purpose of the Study:

  • To develop and validate a novel, image-guided neuronavigation technique for precise targeting of subcortical structures in macaque monkeys.
  • To enable accurate chronic and semi-chronic in-vivo electrophysiological recordings from deep brain regions.
  • To improve upon existing stereotactic methods by incorporating subject-specific anatomical data and minimizing invasiveness.

Main Methods:

  • Incorporation of stable fiducial markers within a custom cranial cap for enhanced image-guided neuronavigation.
  • Utilizing anchor bolt chambers for minimally invasive brain access during chronic recordings.
  • Development and application of a 3D-printed microdrive for semi-chronic electrode implantation.

Main Results:

  • Achieved an average Euclidean targeting error of 1.6 mm and a radial error of 1.2 mm across three implantations in two animals.
  • Successfully recorded extracellular neuronal activity using chronic and semi-chronic implantation methods.
  • Demonstrated single-neuron activity from one macaque monkey, validating the recording capabilities.

Conclusions:

  • The developed protocol offers a flexible, subject-specific approach for targeting deep brain structures with high accuracy.
  • The use of anchor bolt chambers reduces craniotomy size and associated infection risks compared to conventional methods.
  • The 3D-printed microdrive simplifies semi-chronic recording applications, offering an advantage over complex existing systems.