Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Cochlea01:13

The Cochlea

45.2K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.2K
Anatomy of the Ear01:16

Anatomy of the Ear

8.5K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting rapidly cycling receptors CD2 and CD7 increases nanoparticle delivery to primary CD4<sup>+</sup> T cells.

Nature communications·2026
Same author

Targeted Coacervates Enabled by Polyphenol-Peptide Networks for Therapeutic Delivery.

Journal of the American Chemical Society·2026
Same author

Deployable 3D-Printed Vascular Stent with Surface-Catalysed Endogenous Nitric Oxide Generation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Engineering Metal-Phenolic Network Materials through Compositional Tuning of Phenolic Molecules.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Polyphenol-Mediated Antibody Functionalization of Titanium Peroxide Nanoparticles for Cancer Cell Targeting.

ACS applied bio materials·2025
Same author

Amplifying the Immune Activity of Metal Ions through Metal-Phenolic Complexation.

ACS nano·2025

Related Experiment Video

Updated: Jul 19, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.5K

Developing the supraparticle technology for round window-mediated drug administration into the cochlea.

Niliksha Gunewardene1, Yutian Ma2, Patrick Lam3

  • 1Bionics Institute, East Melbourne, Victoria 3002, Australia; Department of Medical Bionics, The University of Melbourne, Fitzroy, Victoria 3065, Australia.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 12, 2023
PubMed
Summary

Silica supraparticles (SPs) show promise for sustained delivery of Neurotrophin 3 (NT3) across the round window membrane (RWM) to treat hearing loss. Coated SPs improved drug retention in the cochlea, with detectable levels up to 8 weeks.

Keywords:
Drug deliveryHearing lossNeurotrophin-3PharmacokineticsSupraparticles

More Related Videos

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.3K
A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
06:55

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus

Published on: February 27, 2018

8.7K

Related Experiment Videos

Last Updated: Jul 19, 2025

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.5K
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

13.3K
A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
06:55

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus

Published on: February 27, 2018

8.7K

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Otolaryngology

Background:

  • The round window membrane (RWM) is a critical barrier for localized drug delivery to the cochlea, essential for treating hearing loss.
  • Neurotrophin 3 (NT3) shows therapeutic potential for hearing loss, but requires sustained delivery across the RWM.
  • Silica supraparticles (SPs) offer potential for long-term drug delivery but require optimization for RWM implantation.

Purpose of the Study:

  • To evaluate strategies for enhancing the longevity and biodistribution of NT3 delivered via SPs across the RWM in animal models.
  • To investigate the efficacy of coated SPs, a fibrin sealant formulation, and RWM permeabilization for improved cochlear drug delivery.

Main Methods:

  • Radioactive iodine-125 labeled NT3 (125I NT3) was loaded into SPs and coated SPs ((Chi/Alg)SPs) to assess drug release kinetics in vitro.
  • SPs and (Chi/Alg)SPs were implanted onto the RWM in guinea pigs and cats, with some formulations combined with fibrin sealant.
  • Cochlear drug retention and distribution were quantified using gamma counting and histological analysis of cochlear tissues.

Main Results:

  • Coated (Chi/Alg)SPs demonstrated a more linear NT3 release profile and significantly slower in vitro release over 7 days compared to uncoated SPs.
  • In vivo, SPs and (Chi/Alg)SPs showed improved NT3 retention and distribution within the cochlea of guinea pigs and cats up to 8 weeks post-implantation.
  • Hyaluronic acid treatment did not significantly enhance acute drug entry across the RWM.

Conclusions:

  • Silica supraparticles, particularly the coated (Chi/Alg)SPs, facilitate NT3 transfer across the RWM, achieving sustained drug presence in the cochlea.
  • In vivo results indicate better drug retention than predicted by in vitro release, highlighting the complexity of the RWM barrier.
  • Further understanding of the RWM's physical properties is crucial for developing effective therapies for hearing loss.