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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

215
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
215
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

173
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
173
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

170
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
170
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

485
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
485
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

291
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
291
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

355
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355

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Related Experiment Video

Updated: Jul 19, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Ulcerative colitis.

Catherine Le Berre1, Sailish Honap2, Laurent Peyrin-Biroulet3

  • 1Institut des Maladies de l'Appareil Digestif, Hépato-Gastro-Entérologie et Assistance Nutritionnelle, Inserm CIC 1413, Inserm UMR 1235, Nantes Université, CHU Nantes, Nantes, France.

Lancet (London, England)
|August 12, 2023
PubMed
Summary

Ulcerative colitis, a chronic gut inflammation, affects millions globally. New treatments aim for remission and endoscopic healing, but some patients still need surgery, highlighting the need for precision medicine.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon, with increasing global prevalence.
  • UC pathogenesis involves genetic predisposition, environmental factors, gut barrier dysfunction, microbiota alterations, and immune dysregulation.
  • Diagnosis relies on clinical, biological, endoscopic, and histological assessments.

Purpose of the Study:

  • To outline the current understanding and management of ulcerative colitis.
  • To review therapeutic strategies for inducing and maintaining remission in UC.
  • To explore future directions in UC treatment, emphasizing precision and personalized medicine.

Main Methods:

  • Review of current medical literature on ulcerative colitis.
  • Analysis of diagnostic criteria and treatment modalities for UC.
  • Discussion of emerging therapeutic targets and approaches.

Main Results:

  • Current treatments include 5-aminosalicylic acid drugs, corticosteroids, thiopurines, biologics, and small molecules for UC management.
  • Despite therapeutic advancements, 10-20% of UC patients require proctocolectomy due to refractory disease.
  • Expanding therapeutic options offer hope, but challenges remain in achieving long-term remission and preventing disability.

Conclusions:

  • Effective management of ulcerative colitis requires inducing rapid clinical response and maintaining long-term remission with normalized biomarkers and endoscopic healing.
  • The combination of therapeutics, precision medicine, and personalized approaches may overcome current treatment limitations in ulcerative colitis.
  • Continued research into UC pathogenesis and novel therapeutic strategies is crucial for improving patient outcomes.