A highly sensitive fluorescence "on-off-on" sensing platform for captopril detection based on AuNCs@ZIF-8...

Here, a novel fluorescent sensing strategy is established for the detection of captopril (CP) sensitively on the basis of a nanocomposite of gold nanoclusters (AuNCs) and metal-organic framework (AuNCs@ZIF-8). The aggregation-induced emission (AIE) effect will be triggered when AuNCs is encapsulated by metal-organic framework (MOF) which served as a carrier since it limits the molecular motion of AuNCs, and the fluorescence of AuNCs greatly enhanced about 5-time after forming the nanocomposites of AuNCs@ZIF-8. The strong orange-emission at 562 nm was quenched in the presence of mercury ions through dynamic quenching. After adding captopril, the quenched fluorescence of AuNCs@ZIF-8/Hg²⁺ system would be restored due to the specific interaction among captopril with mercury ions. Simultaneously, the restored degree of AuNCs@ZIF-8/Hg²⁺ fluorescence depended on the concentration of captopril. Hence, with AuNCs@ZIF-8 serving as reporter signal, the captopril content can be monitored by an "on-off-on" fluorescence sensing mode with a linear relationship of 1-100 μM, and the limit of detection for captopril was 0.134 μM.