Related Experiment Video

Updated: Jul 19, 2025

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
11:13

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Published on: May 24, 2021

6.4K

Multicentre medicoeconomic evaluation of cardiac magnetic resonance imaging for predicting coronary artery disease in

Louis-Marie Desroche1, Damien Mandry2, Gregory Ducrocq3

  • 1Cardiology Department, CHU de la Réunion, allée des Topazes, 97490 Saint-Denis, France.

Archives of Cardiovascular Diseases
|August 12, 2023
PubMed

Insights

Cardiac magnetic resonance imaging (CMR) offers a non-invasive method to assess coronary artery disease in patients with reduced ejection fraction. The CAMAREC study validates CMR

Area of Science:

  • Cardiovascular Imaging
  • Diagnostic Accuracy Studies
  • Non-invasive Cardiology

Background:

  • Unexplained reduced left ventricular ejection fraction (LVEF) often necessitates differentiation between ischemic and non-ischemic cardiomyopathy.
  • Coronary angiography, while definitive, is invasive and carries risks.
  • Cardiac magnetic resonance imaging (CMR) presents a potential non-invasive alternative for etiological assessment.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of CMR in predicting significant coronary artery disease (CAD).
  • To compare CMR's performance against coronary angiography (CAG), the gold standard.
  • To assess CMR's utility in patients with unexplained reduced LVEF (≤ 45%).

Main Methods:

  • Prospective cohort study (CAMAREC) involving 406 patients across 10 centers.
  • Patients underwent CMR followed by CAG within a 2-week interval.
  • Primary outcome: Sensitivity of CMR for detecting ischemic scar indicative of significant CAD (Felker's criteria); secondary outcomes include specificity, predictive values, concordance, and impact on revascularization decisions.

Main Results:

  • The study is designed to rigorously assess the sensitivity, specificity, and predictive values of CMR.
  • Analysis will determine the concordance between CMR and CAG in identifying affected myocardial territories.
  • Ancillary studies will investigate cost-effectiveness and the role of T1-mapping.

Conclusions:

  • The CAMAREC study protocol is established to rigorously evaluate CMR as a non-invasive diagnostic tool.
  • Findings are expected to provide robust evidence for CMR's clinical utility in managing patients with reduced LVEF.
  • Results may influence clinical practice by supporting CMR as a preferred alternative to invasive angiography.
Abstract

Keywords:
Cardiac magnetic resonance imagingCoronary angiographyIschaemic cardiomyopathyLeft ventricular ejection fractionNon-ischaemic cardiomyopathy

More Related Videos

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

456
Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

10.0K

Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
60
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
42
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
10
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
39
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
218
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
23