Distinction between rhinitis alone and rhinitis with asthma using interactomics

Area of Science:

• Immunology
• Genomics
• Systems Biology

Background:

• The
• one-airway-one-disease
• concept suggests allergic diseases are linked.
• Genomic studies indicate distinct pathways for rhinitis alone versus rhinitis with asthma.

Purpose of the Study:

• To differentiate molecular mechanisms of allergic rhinitis alone and in multimorbidity with asthma using human interactome data.
• To investigate differences in pathway topology and associated biological processes between these two phenotypes.

Main Methods:

• Utilized human interactome data within the MeDALL (Mechanisms of the Development of Allergy) study.
• Analyzed and compared molecular pathways and network topology for rhinitis alone and rhinitis with asthma multimorbidity phenotypes.

Main Results:

• Significant differences observed in interactome topology and associated pathways between the two phenotypes.
• Rhinitis alone pathways: cell cycle, cytokine signalling, developmental biology, immune system, protein metabolism, signal transduction. Toll-like receptors and IL-17 signalling identified.
• Rhinitis with asthma pathways: predominantly signal transduction, with some cytokine signalling, immune system, and developmental biology. IL-33 identified.

Conclusions:

• Rhinitis alone and rhinitis with asthma multimorbidity exhibit distinct molecular mechanisms and pathway associations.
• These findings challenge the
• one-airway-one-disease
• concept, supporting the classification of these conditions as separate diseases.