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Updated: Jul 19, 2025

Chromatographic Fingerprinting by Template Matching for Data Collected by Comprehensive Two-Dimensional Gas Chromatography
Published on: September 2, 2020
Multidimensional chromatography in environmental analysis: Comprehensive two-dimensional liquid versus gas
Regina M B O Duarte1, Pedro F Brandão1, Armando C Duarte1
1Department of Chemistry, CESAM - Centre for Environmental and Marine Studies, University of Aveiro, Aveiro 3810-193, Portugal.
Comprehensive two-dimensional liquid chromatography (LC × LC) offers unique advantages for environmental sample analysis, yet its adoption lags behind gas chromatography (GC × GC). This review examines reasons for LC × LC
Area of Science:
- Analytical Chemistry
- Environmental Science
- Chromatography
Background:
- Complex environmental matrices contain numerous compounds, challenging traditional analytical methods.
- Multidimensional chromatography, such as GC × GC and LC × LC, provides enhanced separation power for complex samples.
Conclusions:
- LC × LC possesses unique strengths for environmental analysis that are currently under-exploited.
- Addressing technical and data handling challenges can increase the adoption and success of LC × LC.
- Practical recommendations are provided to promote the use of LC × LC in environmental research.
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