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Updated: Jul 19, 2025

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Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
Published on: May 18, 2016
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Does attenuated plasmodial sporozoite-mediated protection require peroxynitrite?
1Nykode Therapeutics ASA, Oslo Science Park, Gaustadalléen 21, 0349 Oslo, Norway.
Trends in Parasitology
|August 13, 2023
Abstract:
Attenuated plasmodial sporozoite-induced immune response includes intrahepatic nitric oxide (NO) production, which promotes apoptosis of infected hepatocytes and consequent parasite clearance. NO in excess reacts with superoxide, forming peroxynitrite, a powerful cytotoxic agent. Here, I suggest that peroxynitrite proapoptotic action may contribute to the attenuated malarial sporozoite-mediated protection.
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