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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Proton therapy in the palliative setting.

M Judy Lubas1, Patricia Mae G Santos2, Divya Yerramilli2

  • 1Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Annals of Palliative Medicine
|August 13, 2023
PubMed
Summary
This summary is machine-generated.

Proton beam therapy (PBT) shows promise for palliative care, offering symptom management and disease control with potentially reduced toxicity. This review explores its efficacy and safety across various cancer types.

Keywords:
End-of-life careadvanced modalitiespalliative carepalliative radiation therapyproton therapy

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Proton beam therapy (PBT) is established for definitive cancer treatment due to precise dose delivery and sparing of healthy tissues.
  • Photon therapy remains standard for palliative care owing to cost and availability, despite PBT's potential benefits.

Approach:

  • This review synthesizes current literature on PBT's efficacy and safety in the palliative setting for adult patients.
  • It examines studies investigating PBT for symptom management and disease control in advanced, recurrent, or metastatic cancers.

Key Points:

  • PBT may improve symptom control and disease management in palliative cancer care.
  • Its dosimetric properties suggest potential for reduced toxicity and enhanced quality of life, particularly for end-of-life patients.
  • Emerging data from retrospective and prospective trials indicate promising outcomes for PBT in palliative settings.

Conclusions:

  • PBT presents a viable option for palliative radiation therapy, potentially offering superior outcomes and tolerability.
  • Further research is warranted to fully establish PBT's role in palliative oncology.
  • This review is the first to comprehensively examine PBT's application across multiple disease sites in palliative care.