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EphrinB2: Expression of a novel potential target in renal cell carcinoma

Chhavi Gupta1,2, Akash Pramod Sali1,2, Alexandra Jackovich1,3

  • 1Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Indian Journal of Urology : IJU : Journal of the Urological Society of India
|August 14, 2023
PubMed
Abstract

Insights

EphrinB2 is expressed in 47.7% of renal cell carcinoma (RCC) cases, with higher prevalence in males. This finding suggests EphrinB2 may be an early event in RCC development, offering a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Renal cell carcinoma (RCC) management relies on surgery and targeted therapy for metastatic disease.
  • Emerging targeted therapies include the Eph-ephrin pathway, with demonstrated potential in various solid tumors.
  • Limited studies have investigated EphrinB2 expression in RCC.

Purpose of the Study:

  • To determine the immunohistochemical expression of EphrinB2 in renal cell carcinoma (RCC).
  • To evaluate the correlation of EphrinB2 expression with clinicopathological features in RCC.

Main Methods:

  • Immunohistochemical staining for EphrinB2 was performed on a tissue microarray of 88 RCC cases and 10 normal kidney tissues.
  • Expression was assessed in tumor and endothelial cells.
  • Correlations were analyzed with sex, histological subtypes, and tumor nodes metastasis (TNM) stage.

Main Results:

  • EphrinB2 was expressed in 42 out of 88 RCC tumors (47.7%), and was negative in normal kidney tissue.
  • A statistically significant difference in EphrinB2 expression was observed between males (55%) and females (32%).
  • No significant differences in expression were found across histological subtypes or TNM stages, though 51% of Stage 1 and 2 tumors were positive.

Conclusions:

  • EphrinB2 is expressed in approximately half of RCC cases.
  • The presence of EphrinB2 in early-stage tumors suggests it may be an early event in RCC pathogenesis.
  • Targeting the EphrinB2 pathway represents a potential therapeutic strategy for RCC.

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