Sequence effect on the self-assembly of discrete amphiphilic co-oligomers with fluorene-azobenzene semirigid...

Sequences can have a dramatic impact on the unique properties and self-assembly in natural macromolecules, which has received increasing interest. Herein, we report a series of discrete amphiphilic co-oligomers with the same composition but different building blocks in a semirigid backbone. These sequence-defined oligomers possess two primary amine groups on the side chain of the azobenzene building block, and hence, they become amphipathic due to quaternization of the amine groups when protonated in acidic aqueous solution. These oligomer isomers assembled into different nanoparticles, including nanofibers, hollow vesicles and spherical micellar complexes, in a THF/water/HCl mixture under the same conditions. UV-vis absorption spectra, differential scanning calorimetry (DSC) and X-ray scattering (XRD) experiments combined with theoretical calculations reveal that the sequence-controlled co-oligomers induce different molecular packing conformations and arrangement modes of building blocks in self-assembly. Furthermore, these self-assembled nanoparticles demonstrate photoresponsive morphological transformation and fluorescence emission under UV light irradiation due to trans-to-cis photoisomerization of azobenzene. This work demonstrates that customizing functional nanoparticles can be achieved by controlling the sequence structure in synthetic co-oligomers.