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T-cell Large Granular Lymphocytic Leukemia and Felty Syndrome in Rheumatoid Arthritis: A Case Report.
Supritha Prasad1, Iman Mushfiq Farooqui2,3, Lujain AlZoubi4,3
1Internal Medicine, University of Illinois at Chicago, Chicago, USA.
Cureus
|August 14, 2023
Summary
T-cell large granular lymphocytic leukemia, often seen with rheumatoid arthritis, shares features with Felty syndrome. This case highlights their potential overlap on a disease spectrum.
Area of Science:
- Hematology
- Immunology
- Rheumatology
Background:
- T-cell large granular lymphocytic (LGL) leukemia involves clonal T-cell proliferation and is linked to rheumatoid arthritis (RA).
- Felty syndrome (FS), characterized by neutropenia and splenomegaly, is also associated with RA.
- Clinical, pathogenic, and genetic similarities suggest FS and T-cell LGL leukemia may be part of the same disease spectrum.
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