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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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A 3D Organotypic Melanoma Spheroid Skin Model
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Amelanotic Malignant Melanoma: A Case Report.

Kunal Karmilkar1, Richard F Norem2

  • 1Anatomy, Edward Via College of Osteopathic Medicine, Louisiana Campus, Monroe, USA.

Cureus
|August 14, 2023
PubMed
Summary

Amelanotic malignant melanoma (AMM), a rare, non-pigmented skin cancer, is challenging to diagnose clinically. Early detection and treatment, including surgery and immunotherapy, significantly improve outcomes for this aggressive melanoma subtype.

Keywords:
amelanotic malignant melanomaamelanotic melanomafull thickness skin graftmalignant melanoma metastasismass resection

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Amelanotic malignant melanoma (AMM) is a rare skin cancer variant, accounting for 2-8% of all melanomas.
  • AMM originates from melanocytes lacking pigment, making clinical diagnosis difficult due to its mimicry of benign lesions.

Observation:

  • A case report details a 62-year-old Caucasian male with a rapidly growing amelanotic malignant melanoma on his right lower extremity.
  • The patient presented with a painless nodule, right inguinal lymphadenopathy, and pitting edema, despite no systemic signs of malignancy.
  • Medical history included basal cell carcinoma, squamous cell carcinoma, and psoriasis, but no prior melanoma.

Findings:

  • Pathology confirmed an ulcerated AMM with metastatic deposit in the right inguinal sentinel lymph node.
  • The patient received adjuvant immunotherapy, leading to complete cancer cell clearance.

Implications:

  • This case underscores the critical need for early diagnosis of amelanotic malignant melanoma.
  • Effective management involves prompt surgical excision and appropriate adjuvant therapy to enhance patient prognosis.
  • Highlights the diagnostic challenges and successful treatment of this rare melanoma subtype.