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Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Caused by Apalutamide: A Case Presentation

Gabriella Martin¹, Evan Lambert¹, Gordon K Wang²

¹Medical School, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

|August 14, 2023

Abstract:

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction that is triggered several weeks after the start of a new medication. This syndrome presents with a variety of clinical symptoms, specifically a manifestation involving a fever followed by a severe rash. A variety of medications are known to trigger DRESS, with the most common being anticonvulsants and allopurinol. Here, we discuss the case of a medication, apalutamide, that caused DRESS in our patient. Early recognition and abrupt discontinuation of the medication is required for the management of this syndrome and to minimize morbidity and mortality.

Keywords:

apalutamide dress drug reaction eosinophilia medication prostate cancer rash side effects

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