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Time From First Contact With Heart Team to Transcatheter Aortic Valve Replacement in the COVID-19 Era
Matthew J Billy1, Zachary Brennan2, Tariq Ahmad3
1General Surgery, Geisinger Commonwealth School of Medicine, Scranton, USA.
Insights
The COVID-19 pandemic significantly delayed transcatheter aortic valve replacement (TAVR) procedures, increasing patient mortality. Healthcare institutions must create strategies to maintain TAVR access during crises to prevent harm.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Public Health
Background:
- Transcatheter aortic valve replacement (TAVR) is the leading method for aortic valve replacement in the U.S.
- The COVID-19 pandemic disrupted elective surgical care, impacting TAVR accessibility.
- Understanding the pandemic's effect on TAVR access and outcomes is crucial.
Purpose of the Study:
- To evaluate the impact of COVID-19 waves on TAVR procedural timing.
- To assess the association between COVID-19 waves and TAVR patient outcomes.
- To identify the need for robust healthcare access mechanisms during public health crises.
Main Methods:
- Retrospective review of a prospectively maintained database and institutional TAVR data.
- Comparison of time to TAVR before and during defined COVID-19 waves.
- Statistical analysis using t-tests to compare pre-COVID-19 and COVID-19 wave data.
Main Results:
- Mean time to TAVR significantly increased during COVID-19 Wave 1 (68.44 days) and Wave 2 (68.94 days).
- All three COVID-19 waves showed a significant increase in post-operative all-cause mortality compared to pre-COVID-19 levels.
- Increased time to TAVR correlates with higher morbidity and mortality, as supported by existing literature.
Conclusions:
- COVID-19 significantly prolonged TAVR procedure times and elevated mortality rates.
- Healthcare institutions need proactive strategies to ensure continuous TAVR access during crises.
- Maintaining timely TAVR access is vital to prevent adverse patient outcomes during pandemics.
Objective:
Transcatheter aortic valve replacement (TAVR) has become the dominant form of aortic valve replacement in the United States. During the Coronavirus disease 2019 (COVID-19) pandemic, access to elective surgical care was decreased, particularly for TAVR patients. In this study, we examine the impact of each COVID-19 "wave," on our patient's access to TAVR procedures and their associated outcomes. Methods: After institutional review board approval, we conducted a retrospective review of a prospectively maintained database and a review of our own center's database to assess time to TAVR pre-COVID-19 and during internally defined COVID-19 "waves." Statistical analysis was conducted via a t-test.
Results:
We measured the time from first contact to TAVR and compared each COVID-19 wave to our institution's pre-COVID-19 data. During Wave 1 and 2 of COVID-19, our mean time to TAVR increased significantly to 68.44 ± 48.66 days (p = 0.05) and 68.94 ± 53.16 days (p = 0.02), respectively. All three COVID-19 waves demonstrated a statistically significant increase in all-cause mortality post-operatively (PO) with mean PO mortality of 2.5 (p = 0.0035), 1.33 (p = 0.0009), and 0.67 (p = 0.006), respectively, compared to pre-COVID-19 data. Conclusions: Multiple studies have shown that increased time from first contact to TAVR results in increased morbidity and mortality. COVID-19 increased our institution's time to TAVR significantly across two waves with an increase in all-cause mortality in each wave. This study highlights the importance that institutions should develop mechanisms to ensure access to care during crises so that patients do not face potentially avoidable harm.
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