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Uric acid and glaucoma: a systematic review and meta-analysis
Mohammad Mohammadi1,2, Adeleh Yarmohammadi3, Amin Salehi-Abargouei4,5,6
1Students' Research and Technology Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Frontiers in Medicine
|August 14, 2023
Summary
This meta-analysis found that glaucoma patients had higher serum uric acid (UA) levels, but the difference was not statistically significant. Further research is needed to explore the link between UA and glaucoma.
Area of Science:
- Ophthalmology
- Neuroscience
- Biochemistry
Background:
- Glaucoma is a leading cause of irreversible blindness due to optic nerve degeneration.
- Uric acid (UA) has shown neuroprotective effects in other neurodegenerative diseases.
- Existing studies on serum UA levels in glaucoma patients yield conflicting results.
Approach:
- A systematic meta-analysis was conducted, searching major scientific databases.
- Included six case-control studies with 1,221 glaucoma patients and 1,342 controls.
- Analyzed serum UA concentrations using a random-effects model.
Key Points:
- Glaucoma patients exhibited higher mean serum UA levels compared to controls (0.13 difference).
- The observed difference in UA levels was not statistically significant (p > 0.05).
- High heterogeneity (I² = 91.92%) was noted among the included studies.
Conclusions:
- Current evidence suggests a trend towards higher serum UA in glaucoma, but it lacks statistical significance.
- The association between elevated uric acid and glaucoma pathogenesis requires further investigation.
- Prospective studies are recommended to clarify the role of UA in glaucoma.
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