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Effects of atropine 0.01% on refractive errors in children with myopia

Xingxue Zhu1,2,3, Yuliang Wang1,2,3, Yujia Liu1,2,3

  • 1Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.

Heliyon
|August 14, 2023
PubMed

Insights

Low-dose atropine eye drops effectively slow myopia progression in children. However, treatment led to a small but significant increase in total astigmatism, primarily due to changes in corneal astigmatism.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Myopia Control

Background:

  • Astigmatism changes during atropine treatment are not well understood.
  • Myopia is a growing concern in pediatric populations.
  • Atropine eye drops are used for myopia management.

Purpose of the Study:

  • To investigate the effects of 0.01% atropine eye drops on spherical and cylindrical refractive errors in myopic children.
  • To evaluate changes in total astigmatism (TA), corneal astigmatism (CA), and residual astigmatism (RA) during atropine treatment.

Main Methods:

  • A randomized controlled trial involving myopic children aged 6-14 years.
  • Participants received either 0.01% atropine eye drops nightly or single-vision lenses alone.
  • Cycloplegic refraction and axial length were measured over a 9-month follow-up period.

Main Results:

  • Atropine treatment significantly reduced myopia progression compared to controls (spherical equivalent: -0.35 vs. -0.56 D; axial length: 0.20 vs. 0.33 mm).
  • A statistically significant increase in total astigmatism (TA) was observed in the atropine group (-0.14 D) compared to the control group (-0.04 D).
  • The increase in TA was primarily driven by changes in corneal astigmatism (CA).

Conclusions:

  • 0.01% atropine eye drops are effective in preventing myopia progression in children.
  • Nine months of atropine treatment resulted in a small but statistically significant increase in total astigmatism.
  • The findings suggest careful monitoring of astigmatism is warranted during low-dose atropine therapy for myopia control.
Abstract

Keywords:
AstigmatismAtropineMyopiaRefractive error

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