The identification of blood pressure variation with hypovolemia based on the volume compensation method

Objective: The purpose of this study is to identify the blood pressure variation, which is important in continuous blood pressure monitoring, especially in the case of low blood volume, which is critical for survival. Methods: A pilot study was conducted to identify blood pressure variation with hypovolemia using five Landrace pigs. New multi-dimensional morphological features of Photoplethysmography (PPG) were proposed based on experimental study of hemorrhagic shock in pigs, which were strongly correlated with blood pressure changes. Five machine learning methods were compared to develop the blood pressure variation identification model. Results: Compared with the traditional blood pressure variation identification model with single characteristic based on single period area of PPG, the identification accuracy of mean blood pressure variation based on the proposed multi-feature random forest model in this paper was up to 90%, which was 17% higher than that of the traditional blood pressure variation identification model. Conclusion: By the proposed multi-dimensional features and the identification method, it is more accurate to detect the rapid variation in blood pressure and to adopt corresponding measures. Significance: Rapid and accurate identification of blood pressure variation under low blood volume ultimately has the potential to effectively avoid complications caused by abnormal blood pressure in patients with clinical bleeding trauma.