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Restlessness with manic episodes induced by right-sided multiple strokes after COVID-19 infection: A case report

Takahiko Nagamine1,2

  • 1Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu, Yamaguchi, Japan.

Brain Circulation
|August 14, 2023
PubMed

Insights

Coronavirus infection 2019 (COVID-19) can lead to ischemic stroke, particularly in the elderly. This case study highlights a rare instance of mania following COVID-19, linked to right-sided strokes and impaired blood flow.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Psychiatry

Background:

  • Ischemic stroke is a known complication of COVID-19, especially in elderly populations.
  • Post-stroke mood disorders like depression are common, but manic episodes are rarely reported.

Observation:

  • An elderly patient developed mania shortly after recovering from COVID-19.
  • The patient experienced multiple right-sided strokes, with mania onset coinciding with the stroke diagnosis.

Findings:

  • The patient's manic symptoms improved as the strokes stabilized, suggesting a link between impaired blood flow and mania.
  • Right-sided strokes may lead to relative left-hemisphere hyperperfusion, potentially inducing manic symptoms.

Implications:

  • Multiple right-sided strokes following COVID-19 infection can manifest as mania.
  • Further research is needed to elucidate the mechanisms of post-stroke mania.

Keywords:
COVID-19manic episodemultiple strokesright-left imbalance of blood flow

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