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Biocompatible Drug Delivery System Based on a MOF Platform for a Sustained and Controlled Release of the Poorly

Preety Yadav1, Sarita Kumari1, Anand Yadav1

  • 1Department of Chemistry, School of Basic Sciences, Central University of Haryana, Jant-Pali, Mahendergarh 123031, Haryana, India.

ACS Omega
|August 14, 2023
PubMed

Insights

This study developed a new drug delivery system using metal-organic frameworks (MOFs) to improve norfloxacin (NFX) delivery. The biocompatible NFX@MIL-100(Fe) system enhanced drug loading and controlled release, showing potential for pharmaceutical applications.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Science

Background:

  • Norfloxacin (NFX), a fluoroquinolone antibiotic, exhibits poor solubility and permeability (Biopharmaceutics Classification System Class IV).
  • These physicochemical limitations hinder effective drug delivery and pose challenges for pharmaceutical development.
  • Developing novel drug delivery systems (DDSs) is crucial for improving the therapeutic efficacy of poorly soluble drugs like NFX.

Purpose of the Study:

  • To develop a novel DDS for norfloxacin (NFX) using a biocompatible metal-organic framework (MOF), MIL-100(Fe).
  • To characterize the drug-loaded MOF (NFX@MIL-100(Fe)) and evaluate its drug loading capacity and release profile.
  • To assess the biocompatibility and cytotoxicity of the developed DDSs.

Main Methods:

  • Norfloxacin was loaded onto the MIL-100(Fe) MOF platform.
  • Characterization of NFX@MIL-100(Fe) using FTIR, UV-Vis spectroscopy, TGA, and nitrogen adsorption.
  • Controlled release studies and PEGylation of NFX@MIL-100(Fe) to create PEG{NFX@MIL-100(Fe)}.
  • Biocompatibility and cytotoxicity assessment using MTT assay.

Main Results:

  • High drug loading (approximately 20 wt%) of NFX onto MIL-100(Fe) was achieved.
  • The NFX@MIL-100(Fe) system demonstrated sustained drug release.
  • PEGylation of the DDS further controlled norfloxacin release.
  • Toxicity studies confirmed the biocompatibility of both NFX@MIL-100(Fe) and PEG{NFX@MIL-100(Fe)} DDSs with insignificant cytotoxicity.

Conclusions:

  • Metal-organic framework MIL-100(Fe) serves as an effective platform for developing a novel drug delivery system for norfloxacin.
  • The developed DDSs (NFX@MIL-100(Fe) and PEG{NFX@MIL-100(Fe)}) exhibit high drug loading, controlled release, and excellent biocompatibility.
  • This approach offers a promising strategy for enhancing the delivery and therapeutic potential of poorly soluble drugs like norfloxacin.

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