Tailoring mSiO₂-SmCo_x nanoplatforms for magnetic/photothermal effect-induced hyperthermia therapy

Hyperthermia therapy is a hotspot because of its minimally invasive treatment process and strong targeting effect. Herein, a synergistic magnetic and photothermal therapeutic nanoplatform is rationally constructed. The well-dispersive mSiO₂-SmCo_x nanoparticles (NPs) were synthesized through a one-step procedure with the regulated theoretical molar ratio of Sm/Co among 1:1, 1:2, and 1:4 for controlling the dispersion and magnetism properties of SmCo_x NPs in situ growth in the pore structure of mesoporous SiO₂ (mSiO₂), where mSiO₂ with diverse porous structures and high specific surface areas serving for locating the permanent magnetic SmCo_x NPs. The mSiO₂-SmCo_x (Sm/Co = 1:2) NPs with highly dispersed and uniform morphology has an average diameter of ∼73.08 nm. The photothermal conversion efficiency of mSiO₂-SmCo_x (Sm/Co = 1:2) NPs was determined to be nearly 41%. The further in vitro and in vivo anti-tumor evaluation of mSiO₂-SmCo_x (Sm/Co = 1:2) NPs present promising potentials for hyperthermia-induced tumor therapy due to magnetic and photothermal effects.