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Iterative prototyping based on lessons learned from the falloposcope in vivo pilot study experience.

Andrew D Rocha1, William K Drake1, Photini F Rice2

  • 1The University of Arizona, Wyant College of Optical Science, Tucson, Arizona, United States.

Journal of Biomedical Optics
|August 14, 2023
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Summary

Early detection of ovarian cancer is crucial. A novel falloposcope using multispectral fluorescence imaging and optical coherence tomography successfully imaged fallopian tubes, paving the way for earlier diagnosis.

Keywords:
endoscopic optical coherence tomographyfallopian tubein vivo imagingmicroendoscope iterative design and prototypingmultispectral fluorescence imagingovarian cancer

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Area of Science:

  • Gynecological oncology
  • Medical imaging
  • Biomedical engineering

Background:

  • High-grade serous ovarian cancer, the deadliest gynecological cancer, often originates in the fallopian tubes (FTs).
  • Early detection significantly improves survival rates, but current methods are limited.
  • Autofluorescence imaging, multispectral fluorescence imaging (MFI), and optical coherence tomography (OCT) show promise for detecting precancerous and cancerous lesions in FTs and ovaries.

Purpose of the Study:

  • To develop and evaluate a novel falloscope for in vivo imaging of the fallopian tubes (FTs) using MFI and OCT.
  • To assess the safety and feasibility of FT imaging prior to salpingectomy in a pilot study.
  • To describe iterative improvements made to the falloscope based on clinical feedback.

Main Methods:

  • Development of a clinical prototype falloscope with a diameter.
  • Minimally invasive introduction via a hysteroscope and catheter.
  • Acquisition of navigation video, MFI, and OCT images of human FTs in 12 volunteers.

Main Results:

  • The falloscope successfully acquired in vivo images of the fallopian tubes.
  • Iterative improvements enhanced device robustness, usability, and image quality.
  • Feedback from stakeholders guided modifications to the imaging system and accessories.

Conclusions:

  • The falloposcope is a feasible tool for in vivo imaging of the fallopian tubes.
  • Iterative prototyping has significantly improved the device's robustness and functionality.
  • Further trials are warranted to establish the falloscope's role in early ovarian cancer detection.