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3D double-reinforced graphene oxide - nanocellulose biomaterial inks for tissue engineered constructs
Alexandra I Cernencu1, George M Vlasceanu1,2, Andrada Serafim1
1Advanced Polymer Materials Group, University Politehnica of Bucharest 1-7 Gh. Polizu Street Bucharest 011061 Romania mariana.ionita@polimi.it.
RSC Advances
|August 14, 2023
Summary
Researchers developed enhanced 3D printable bone scaffolds using a gelatin/pectin matrix with graphene oxide (GO). The addition of GO improved mechanical strength, printability, and scaffold fidelity for bone tissue engineering applications.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Regenerative Medicine
Background:
- 3D printing enables patient-specific bone tissue engineering and in vitro models.
- Natural polymer-based inks often lack mechanical strength, stability, and osteogenic potential.
Purpose of the Study:
- To develop novel, printable biomaterial formulations for bone tissue engineering.
- To enhance mechanical properties and printability of bone scaffolds using graphene oxide (GO) and nanocellulose.
Main Methods:
- Utilized a gelatin/pectin polymeric matrix.
- Incorporated graphene oxide (GO) and oxidized nanocellulose fibers (CNF) as reinforcement.
- Employed 3D printing technology to fabricate bone-like scaffolds with varying GO concentrations (0.25%, 0.5%, 1%).
Main Results:
- 3D scaffolds were successfully printed with enhanced compressive modulus, printability, and fidelity.
- The addition of GO significantly improved scaffold properties compared to pure gelatin/pectin systems.
- The formulation with 0.5% GO demonstrated the most promising results.
Conclusions:
- Novel composite hydrogel inks show significant potential for 3D bone tissue engineering.
- Optimized GO concentration (0.5%) enhances scaffold performance for bone regeneration applications.
- These findings support the development of advanced biomaterials for patient-specific therapies.
