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Updated: Jul 19, 2025

Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
A rare case of pseudomyxoma peritonei with Morgagni hernia
Toru Imagami1, Yasumitsu Oe1, Byonggu An1
1Department of Digestive Surgery and Peritoneal Dissemination Center, Omi Medical Center, 1660, Yabase, Kusatsu, Shiga 525-8585 Japan.
Abstract:
Both pseudomyxoma peritonei and Morgagni hernias in adults are rare clinical conditions. A 70-year-old woman who was diagnosed with pseudomyxoma peritonei with Morgagni hernia underwent cytoreductive surgery and primary repair. Pseudomyxoma peritonei causes increased intra-abdominal pressure that may lead to acquired congenital diaphragmatic hernia when there is a local fragility in the diaphragmatic musculature. Parietal peritonectomy of the right diaphragmatic peritoneum can safely remove the hernia sac. The high rate of infections associated with cytoreductive surgery causes hesitation for concurrent mesh repair for Morgagni hernia. This is the first report of pseudomyxoma peritonei with Morgagni hernia. Cytoreductive surgery including parietal peritonectomy of the right diaphragmatic peritoneum plus primary repair of hernial defect was performed safely and successfully, which achieved positive short-term results for patients with pseudomyxoma peritonei-associated Morgagni hernia.
Insights
This study reports the first case of pseudomyxoma peritonei with Morgagni hernia in an adult. Cytoreductive surgery with primary repair proved safe and effective for this rare combined condition.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Abdominal Surgery
Background:
- Pseudomyxoma peritonei and Morgagni hernias are rare adult conditions.
- Pseudomyxoma peritonei can increase intra-abdominal pressure, potentially causing acquired diaphragmatic hernias.
- The combination of pseudomyxoma peritonei and Morgagni hernia is unprecedented.
Purpose of the Study:
- To describe the first reported case of pseudomyxoma peritonei with Morgagni hernia in an adult.
- To evaluate the safety and efficacy of cytoreductive surgery and primary repair for this combined pathology.
Main Methods:
- A 70-year-old female patient diagnosed with pseudomyxoma peritonei and Morgagni hernia underwent surgical intervention.
- The procedure included cytoreductive surgery and primary repair of the hernial defect.
- Parietal peritonectomy of the right diaphragmatic peritoneum was performed to address the hernia sac.
Main Results:
- The combined cytoreductive surgery and primary repair were performed safely and successfully.
- The surgical approach achieved positive short-term outcomes for the patient.
- Parietal peritonectomy effectively removed the hernia sac without complications.
Conclusions:
- This case demonstrates the feasibility of combined cytoreductive surgery and primary repair for pseudomyxoma peritonei with Morgagni hernia.
- The surgical strategy offers a safe and effective treatment option for this rare dual diagnosis.
- Further research may explore long-term outcomes of this combined surgical approach.
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