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Updated: Oct 21, 2026
Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
[Carcinoma of the extrahepatic bile duct in young child--a case report]
Insights
A rare case of distal common bile duct adenocarcinoma in a 2-year-old child presented with jaundice and abdominal mass. Surgical resection was successful, highlighting the importance of early diagnosis and treatment for this uncommon pediatric cancer.
Area of Science:
- Pediatric Oncology
- Surgical Gastroenterology
- Hepatobiliary Surgery
Background:
- Distal common bile duct adenocarcinoma is exceptionally rare in infants and children.
- Early diagnosis and surgical intervention are crucial for managing pediatric biliary tract cancers.
Observation:
- A 2-year-old male presented with severe jaundice, melena, anemia, and an upper abdominal mass.
- Surgical exploration revealed a tumor in the pancreatic head involving the duodenum and distal common bile duct.
Findings:
- Postoperative pathology confirmed adenocarcinoma of the distal common bile duct with invasion of the duodenum and pancreatic head.
- The patient underwent a successful pancreaticoduodenectomy with multi-stage reconstruction without immediate complications.
Implications:
- Radical resection is the primary treatment for resectable distal common bile duct adenocarcinoma in children.
- Despite aggressive treatment, the prognosis for this rare pediatric malignancy remains generally poor, necessitating close follow-up.
- This case underscores the need for increased awareness and diagnostic vigilance for rare biliary cancers in pediatric populations.
Abstract:
A child, 2 years old, male suffering from severe jaundice, melena, severe anemia and right upper abdominal mass was admitted into our hospital. Diagnosis of obstructive jaundice was made before operation. On exploration, a tumor mass was found in the pancreatic head, which involved the duodenum and distal common bile duct. Pancreaticoduodenectomy with one stage pancreaticojejunostomy, choledochojejunostomy and gastrojejunostomy was carried out. Postoperative pathology showed adenocarcinoma of the distal common bile duct invading the periampullary tissues of the duodenum and infiltrating, to a lesser extent, into the pancreatic head. Carcinoma arising from the distal common bile duct is rare in infancy and childhood. Radical resection should be attempted if possible. In general, the prognosis is poor in this tumor. No complication after operation occurred on this patient but close follow-up is necessary. Pathology related to this tumor is discussed with a review of literature.
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