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Published on: November 20, 2015
Categorical Risk Stratification for Neonatal Early Onset Sepsis using Suspected Intraamniotic Infection and the
Anne-Marie Rick1, Elizabeth Copp1, Abigail Buckley1
1University of Pittsburgh.
Objective:
To determine test characteristics of categorical risk stratification for early onset sepsis (EOS) using maternal criteria for suspected intraamniotic infection (IAI) and/or newborn exam and compare them to the EOS calculator.
Study Design:
Retrospective 1:3 case-control study of late preterm/term infants with bacterial culture growth obtained <72 hours of life. For categorical approach, infants of mothers with suspected IAI or equivocal/ill appearing were presumed high-risk for EOS and blood culture obtained. For calculator, estimated probability of EOS and care recommendations were recorded from online calculator. Test characteristics were compared with McNemar's test; recommendation for blood culture was considered a "positive" test.
Result:
52 cases and 172 controls were included. Compared to the calculator, the categorical approach had higher sensitivity 90%(95%CI:79-96%) vs 67% (95%CI:54-79%) but lower specificity 85%(95%CI:78-89%) vs. 92%(95%CI:87-96%). 10% of cases were not identified by either.
Conclusion:
A categorical approach using suspected IAI/newborn exam offers good EOS discrimination and is comparable to the calculator.
