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Drug utilization research in clinical practice.

Y A Hekster, T B Vree

    Drug Intelligence & Clinical Pharmacy
    |September 1, 1986
    PubMed
    Summary
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    Drug utilization studies in clinical practice can optimize prescribing patterns and reduce healthcare costs. Linking drug use data with therapeutic outcomes, using defined endpoints and disease activity indices, establishes drug utilization research as a medical discipline.

    Area of Science:

    • Pharmacoeconomics
    • Clinical Pharmacy
    • Health Services Research

    Background:

    • Pharmacy services significantly influence prescribing habits.
    • Drug utilization studies offer potential for substantial healthcare cost reduction.
    • Current practices necessitate balancing drug use data with patient outcomes.

    Purpose of the Study:

    • To explore the role and future of drug utilization studies in clinical practice.
    • To highlight the importance of assessing therapeutic results alongside drug utilization.
    • To introduce methods for linking drug use to treatment effectiveness.

    Main Methods:

    • Review of existing literature on drug utilization studies.
    • Emphasis on defining measurable endpoints for therapeutic assessment (e.g., infection rates).

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  • Introduction of the Index of Disease Activity (IDA) for tracking disease progression and drug effects in conditions like Crohn's disease, rheumatoid arthritis, and ankylosing spondylitis.

    • Main Results:

    • Pharmacy services impact prescribing patterns and can lead to financial savings.
    • Defined endpoints and disease activity indices enable the assessment of therapeutic outcomes.
    • The Index of Disease Activity (IDA) provides a quantifiable measure of drug impact on disease processes.

    Conclusions:

    • Drug utilization research, when linked with outcome assessment, is a vital medical discipline.
    • Future developments should focus on integrating drug use data with validated therapeutic endpoints.
    • This approach allows for a comprehensive evaluation of drug therapy's value in clinical practice.