Related Experiment Videos
Lidocaine excretion in breast milk
Drug Intelligence & Clinical Pharmacy
|September 1, 1986
Summary
Intravenous lidocaine, used for heart rhythm issues, is excreted in small amounts into breast milk. Nursing mothers can likely continue breastfeeding while on this medication.
Area of Science:
- Pharmacology
- Neonatal Medicine
- Lactation Studies
Background:
- Intravenous lidocaine is sometimes administered to nursing mothers for ventricular dysrhythmias.
- No previous studies have documented lidocaine excretion into human breast milk.
Purpose of the Study:
- To investigate the excretion of lidocaine into breast milk.
- To validate the TDx methodology for whole-milk lidocaine assays.
Main Methods:
- A case study documenting lidocaine levels in a nursing mother's serum and breast milk.
- Utilized TDx methodology for whole-milk lidocaine concentration analysis.
Main Results:
- Lidocaine was detected in breast milk in small quantities.
- Breast milk lidocaine concentrations were approximately 40% of maternal serum levels.
- The TDx assay methodology was validated for this purpose.
Conclusions:
- Lidocaine is excreted into breast milk in minimal amounts.
- Breastfeeding can likely continue safely for mothers receiving parenteral lidocaine.
- Potential adverse effects in infants are likely limited to idiosyncratic or allergic reactions.