Related Experiment Video

Updated: Jul 19, 2025

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
11:35

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA

Published on: August 21, 2016

13.0K

Reduced ADAMTS13 activity and high D-dimer levels are associated with thrombosis in patients with systemic lupus

Tipparat Penglong1, Anuchit Boontanvansom2, Pongtep Viboonjuntra3

  • 1Haematology Unit, Department of Pathology, Faculty of Medicine.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|August 14, 2023
PubMed

Insights

Reduced ADAMTS13 activity and elevated D-dimer levels are key indicators for predicting thrombosis risk in patients with Systemic Lupus Erythematosus (SLE). These findings highlight potential prognostic biomarkers for vascular events in SLE patients.

Area of Science:

  • Rheumatology
  • Hematology
  • Vascular Biology

Background:

  • Systemic Lupus Erythematosus (SLE) patients face a higher risk of vascular thrombosis.
  • There is a critical need for biomarkers to predict thrombosis in SLE patients.

Purpose of the Study:

  • To investigate the potential of ADAMTS13 activity and D-dimer levels as biomarkers for thrombosis risk in SLE patients.

Main Methods:

  • Assessed ADAMTS13 activity, D-dimer levels, and antiphospholipid antibodies in 66 SLE patients (22 with thrombosis, 44 without).
  • Matched cases and controls for age and sex.
  • Collected data on clinical manifestations, disease activity, and risk factors.

Main Results:

  • Significantly lower ADAMTS13 activity and higher D-dimer levels were observed in SLE patients with a history of thrombosis.
  • Receiver operating characteristic analysis confirmed a correlation between reduced ADAMTS13 activity and thrombosis history.
  • Reduced ADAMTS13 activity correlated with increased D-dimer levels specifically in the thrombotic group.

Conclusions:

  • Reduced ADAMTS13 activity and elevated D-dimer levels are associated with thrombosis in SLE.
  • These markers may serve as valuable prognostic indicators for predicting thrombosis in SLE patients.
Abstract

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.0K
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus05:38

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

126

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
753
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17