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Forskolin Improves Male Reproductive Complications Caused by Hyperglycemia in Type 2 Diabetic Rats

Mehran Naghibi1,2, Hamid Tayefi Nasrabadi2, Jafar Soleimani Rad2

  • 1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

International Journal of Fertility & Sterility
|August 14, 2023
PubMed
Abstract

Insights

Forskolin effectively combats male infertility in type 2 diabetes by improving sperm health and testosterone levels. This study shows Forskolin significantly reverses diabetes-induced reproductive dysfunction in rats.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Diabetology

Background:

  • Type 2 diabetes frequently causes male infertility due to spermatogenesis complications.
  • Male reproductive dysfunction is a significant concern in diabetic patients.

Purpose of the Study:

  • To investigate the therapeutic effects of Forskolin on type 2 diabetes-induced male reproductive dysfunction.
  • To evaluate Forskolin's impact on key reproductive parameters and oxidative stress markers in diabetic rats.

Main Methods:

  • Type 2 diabetes was induced in Wistar rats using a high-fat diet and streptozotocin (STZ).
  • Diabetic rats were treated with Forskolin (10 mg/kg) for one month.
  • Key parameters including blood glucose, testosterone levels, sperm parameters, oxidative stress markers (MDA, SOD, GPX), and gene expression (Bax, Bcl-2) were analyzed.

Main Results:

  • Diabetic rats exhibited significantly increased blood glucose, body weight, and MDA levels, alongside decreased testosterone, sperm quality, and antioxidant enzyme activity.
  • Forskolin treatment (G4) normalized these parameters, bringing them closer to control group levels.
  • Forskolin significantly improved sperm concentration, motility, morphology, testosterone levels, and antioxidant status in diabetic rats.

Conclusions:

  • Forskolin demonstrates significant efficacy as an antidiabetic agent in improving male reproductive health.
  • The study highlights Forskolin's potential to reverse diabetes-associated infertility by enhancing sperm parameters and testosterone production.
  • Forskolin treatment effectively mitigates oxidative stress and modulates apoptosis-related gene expression in diabetic testes.
Keywords:
FORSKOLINMale InfertilityOxidative StressTesticular DysfunctionType 2 Diabetes

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