Recommended updates to the USEPA Framework for Metals Risk Assessment: Aquatic ecosystems

In 2007, the USEPA issued its "Framework for Metals Risk Assessment." The framework provides technical guidance to risk assessors and regulators when performing human health and environmental risk assessments of metals. This article focuses on advances in the science including assessing bioavailability in aquatic ecosystems, short- and long-term fate of metals in aquatic ecosystems, and advances in risk assessment of metals in sediments. Notable advances have occurred in the development of bioavailability models for assessing toxicity as a function of water chemistry in freshwater ecosystems. The biotic ligand model (BLM), the multiple linear regression model, and multimetal BLM now exist for most of the common mono- and divalent metals. Species sensitivity distributions for many metals exist, making it possible for many jurisdictions to develop or update their water quality criteria or guidelines. The understanding of the fate of metals in the environment has undergone significant scrutiny over the past 20 years. Transport and toxicity models have evolved including the Unit World Model allowing for estimation of concentrations of metals in various compartments as a function of loading and time. There has been significant focus on the transformation of metals in sediments into forms that are less bioavailable and on understanding conditions that result in resolubilization or redistribution of metals in and from sediments. Methods for spiking sediments have advanced such that the resulting chemistry in the laboratory mimics that in natural systems. Sediment bioavailability models are emerging including models that allow for prediction of toxicity in sediments for copper and nickel. Biodynamic models have been developed for several organisms and many metals. The models allow for estimates of transport of metals from sediments to organisms via their diet as well as their water exposure. All these advances expand the tool set available to risk assessors. Integr Environ Assess Manag 2024;20:924-951. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).