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Percutaneous Renal Tumor Cryoablation Effect on Renal Function.

Jens Steensen Knudsen1,2, Louise Aarup Duus2,3, Theresa Junker2

  • 1Department of Medicine, Faculty of Health Sciences, University of Southern Denmark (SDU), Odense, Denmark.

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Percutaneous cryoablation (PCA) for renal tumors shows minimal impact on kidney function 12 months post-procedure. This study confirms PCA is a safe and effective intervention, even for patients with pre-existing reduced renal function.

Keywords:
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Area of Science:

  • Nephrology
  • Urology
  • Oncology

Background:

  • Percutaneous cryoablation (PCA) is an established treatment for renal tumors.
  • Limited data exists on the long-term renal function post-PCA.
  • Evaluating renal function is crucial for assessing treatment safety and efficacy.

Purpose of the Study:

  • To assess the effects of computed tomography-guided PCA on renal function.
  • To evaluate changes in estimated glomerular filtration rate (eGFR) 12 months after PCA.

Main Methods:

  • Retrospective cohort study of 259 patients undergoing PCA for renal tumors.
  • Collected baseline and 12-month follow-up eGFR data.
  • Analyzed eGFR changes in relation to chronic kidney disease (CKD) stages.

Main Results:

  • Mean eGFR showed a minimal decline from 73.7 to 69.7 mL/min/1.73 m² (p < 0.0001) at 12 months.
  • Most patients maintained or had minimal changes in their CKD stage.
  • No significant eGFR decline was observed in patients with skewed renography treated in the better-functioning kidney.

Conclusions:

  • PCA demonstrates minimal adverse effects on renal function one year after treatment.
  • The procedure is considered safe and relevant for managing renal tumors, including in patients with impaired renal function.