Snakins: antimicrobial potential and prospects of genetic engineering for enhanced disease resistance in plants

Snakins of the Snakin/Gibberellic Acid Stimulated in Arabidopsis (GASA) family are short sequenced peptides consisting of three different regions: a C-terminal GASA domain, an N-terminal signal sequence and a variable region. The GASA domain is comprised of 12 conserved cysteine residues responsible for the structural stability of the peptide. Snakins are playing a variety of roles in response to various biotic stresses such as bacterial, fungal, and nematodes infections and abiotic stress like water scarcity, saline condition, and reactive oxygen species. These properties make snakins very effective biotechnological tools for possible therapeutic and agricultural applications. This review was attempted to highlight and summarize the antifungal and antibacterial potential of snakins, also emphasizing their sequence characteristics, distributions, expression patterns and biological activities. In addition, further details of transgene expression in various plant species for enhanced fungal and bacterial resistance is also discussed, with special emphasis on their potential applications in crop protection and combating plant pathogens.