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Cancer-Specific Survival of Patients with Non-Muscle-Invasive Bladder Cancer: A Population-Based Analysis
Aleksander Ślusarczyk1, Piotr Zapała2, Łukasz Zapała2
1Department of General, Oncological, and Functional Urology, Medical University of Warsaw, Warsaw, Poland. slusarczyk.aleksander@gmail.com.
Annals of Surgical Oncology
|August 14, 2023
Summary
Non-muscle-invasive bladder cancer (NMIBC) carries a significant long-term cancer-specific mortality risk, particularly for T1HG tumors. A new nomogram incorporating clinical and sociodemographic factors aids in predicting prognosis for NMIBC patients.
Area of Science:
- Urology
- Oncology
- Epidemiology
Background:
- Non-muscle-invasive bladder cancer (NMIBC) is a diverse condition with variable prognoses.
- Understanding real-world cancer-specific survival (CSS) is crucial for patient management.
Purpose of the Study:
- To report the real-world CSS of NMIBC.
- To develop a prognostic nomogram for NMIBC based on identified risk factors.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015).
- Included patients who underwent transurethral resection of bladder tumor.
- Developed a prognostic nomogram using Cox proportional hazards analysis.
Main Results:
- Analyzed 98,238 NMIBC patients with a median follow-up of 124 months.
- Cancer-specific mortality (CSM) was highest for T1HG (19.52%) and lowest for TaLG (3.76%).
- The nomogram integrated T category, grade, age, tumor characteristics, histology, race, income, and marital status, achieving an AUC of 0.824 in validation.
Conclusions:
- NMIBC poses a substantial long-term CSM risk, especially in T1HG cases.
- TaHG and T1LG tumors, though less common, indicate a high-risk group with ~10% CSM.
- While T category, grade, and age are primary CSS determinants, sociodemographic factors also impact NMIBC prognosis.
