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Updated: Jul 19, 2025

High-throughput Antiviral Assays to Screen for Inhibitors of Zika Virus Replication
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Published on: October 30, 2021

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Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects

João Locke Ferreira de Araújo1, Victória Frigério Bonifácio2, Lorena Medeiros Batista2

  • 1Grupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Current Microbiology
|August 14, 2023
PubMed

Insights

Genetic variants near the 3p21.31 locus impact COVID-19 outcomes. The CXCR6 rs2234355 polymorphism was linked to increased mortality risk in hospitalized COVID-19 patients.

Area of Science:

  • Genetics
  • Infectious Diseases
  • Genomics

Background:

  • Genome-wide association studies (GWAS) identified the 3p21.31 locus associated with severe COVID-19.
  • Specific polymorphisms within this locus require further investigation for their role in disease severity.

Purpose of the Study:

  • To investigate the association of three polymorphisms (LZTFL1 rs10490770, CXCR6 rs2234355, and rs2234358) in the 3p21.31 locus with COVID-19 prognosis.
  • To determine if these variants correlate with mechanical ventilation, hospitalization duration, or mortality.

Main Methods:

  • A cohort of 102 hospitalized Brazilian COVID-19 patients was genotyped for three specific polymorphisms.
  • Statistical analyses were performed to assess the association between genotypes and clinical outcomes, including mechanical ventilation, hospitalization length, and death.

Main Results:

  • No significant genetic association was found for the need for mechanical ventilation or hospitalization length.
  • The CXCR6 rs2234355 polymorphism showed a significant association with mortality.
  • Carriers of the A/A genotype for CXCR6 rs2234355 had a substantially higher risk of death (OR: 10.5; 95% CI: 1.55-70.76) compared to A/G heterozygotes.

Conclusions:

  • The genetic variant CXCR6 rs2234355 may contribute to COVID-19 related mortality.
  • These findings highlight the potential role of specific genetic factors in determining severe COVID-19 outcomes.

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