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Updated: Jul 19, 2025

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

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CircRNA-regulated glucose metabolism in ovarian cancer: an emerging landscape for therapeutic intervention

Yaolong Wang1,2,3, Xi Chen1,2,3, Yongxiu Yang4,5,6

  • 1Department of Obstetrics and Gynecology, The First Hospital of Lanzhou University, Lanzhou, 730000, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|August 14, 2023
PubMed

Insights

Circular RNAs (circRNAs) significantly impact ovarian cancer (OC) progression by altering glucose metabolism. Targeting circRNAs offers a promising new therapeutic strategy for this deadly disease.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ovarian cancer (OC) exhibits high mortality with limited treatment efficacy.
  • Circular RNAs (circRNAs) are key regulators of gene expression.
  • circRNAs influence OC proliferation, migration, and the Warburg effect.

Purpose of the Study:

  • To review the formation and characteristics of circRNAs.
  • To elucidate the role of circRNAs in regulating OC glucose metabolism.
  • To explore the therapeutic potential of circRNAs in OC.

Main Methods:

  • Literature review on circRNA biogenesis and function.
  • Analysis of circRNA involvement in OC cell metabolism.
  • Evaluation of circRNAs as potential therapeutic targets.

Main Results:

  • circRNAs regulate glucose metabolism-related proteins (e.g., GLUT1, HK2) in OC.
  • circRNAs promote anaerobic glycolysis, increasing glucose uptake and ATP production.
  • Dysregulated circRNA expression supports OC growth and invasion.

Conclusions:

  • circRNAs are critical regulators of glucose metabolism in ovarian cancer.
  • circRNAs present novel therapeutic targets for OC treatment.
  • Further research into circRNAs could improve OC patient outcomes.
Keywords:
CircRNAGlucose metabolismOvarian cancerTargeted therapy

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