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Updated: Oct 8, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
[Enhancement of the antineoplastic effect of local hyperthermia by induced hyperglycemia]
Abstract:
It is shown that the antitumour effect of local hyperthermia (2450 MHz, 43 degrees C, 60 min) is enhanced essentially if it follows immediately after i. v. infusion of 20% glucose solution at a rate of 80 mg X kg-1 X min-1 for 90 min in experiments on rats bearing the Guerin carcinoma. Under such a combined treatment the rate of tumour growth decreases by a factor of 2. An assumption is advanced that such an enhancement of the hyperthermia effect is caused mainly by low pH values of the tumour which are observed under hyperglycemia.
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