Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypercalcemia in glucocorticoid withdrawal.

K Suzuki, K Nonaka, K Ichihara

    Endocrinologia Japonica
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ammonium-bearing phyllosilicate grains detected in Ryugu and Bennu samples via infrared spectroscopy.

    Nature communications·2026
    Same author

    Comparative effectiveness of immunotherapeutic regimens for untreated advanced non-small-cell lung cancer in real-world clinical practice: a Japanese cancer registry cohort study.

    ESMO real world data and digital oncology·2026
    Same author

    Bennu and Ryugu constituents from samples IR analyses and potential source of terrestrial planets' ingredients.

    Nature communications·2025
    Same author

    First Search for Axion Dark Matter with a MADMAX Prototype.

    Physical review letters·2025
    Same author

    First Search for Dark Photon Dark Matter with a madmax Prototype.

    Physical review letters·2025
    Same author

    Near-infrared spectral variation in Ryugu particles and implication for rapid space weathering by solar UV radiation.

    Scientific reports·2025

    Glucocorticoid withdrawal after adrenalectomy can cause severe hypercalcemia. This study shows hypercalcemia resulted from increased bone resorption and calcium reabsorption, not elevated hormones.

    Area of Science:

    • Endocrinology
    • Nephrology
    • Bone Metabolism

    Background:

    • Unilateral adrenalectomy for cortisol-secreting adenomas requires glucocorticoid replacement.
    • Abrupt or gradual withdrawal of glucocorticoids can lead to hormonal imbalances.

    Observation:

    • A patient developed severe hypercalcemia 15 days after hydrocortisone withdrawal post-adrenalectomy.
    • Elevated serum calcium was noted with increased urinary hydroxyproline excretion.
    • Urinary calcium excretion was lower than expected for the serum calcium level.

    Findings:

    • Hypercalcemia was attributed to glucocorticoid withdrawal, not elevated parathyroid hormone (PTH), 25(OH)D, or 1,25(OH)2D.
    • Enhanced bone resorption and increased renal tubular calcium reabsorption were identified as contributing factors.

    Related Experiment Videos

  • Serum calcium, PTH, 25(OH)D, and 1,25(OH)2D levels were measured during the hypercalcemic event.

    • Implications:

    • Highlights a potential complication of glucocorticoid withdrawal in post-adrenalectomy patients.
    • Suggests careful monitoring of calcium levels during hydrocortisone tapering.
    • Underscores the complex interplay between glucocorticoids, bone metabolism, and calcium homeostasis.