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G Protein-coupled Receptors01:15

G Protein-coupled Receptors

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Reply to G. Wang et al

Sjoukje Lubberts1, Flora E van Leeuwen1, Michael Schaapveld1

  • 1Sjoukje Lubberts, MD, Department of Medical Oncology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands; Flora E. van Leeuwen, PhD and Michael Schaapveld, PhD, Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands; and Jourik A. Gietema, MD, PhD, Department of Medical Oncology, University Medical Center Groningen and University of Groningen, Groningen, the Netherlands.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
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PubMed
Summary

No abstract available in PubMed .

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