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[Research progress on cirrhosis reversal and recompensation]
1Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.
Summary
Previously irreversible liver cirrhosis may be reversible. Controlling the cause and managing complications can lead to recompensation in decompensated liver cirrhosis patients, improving outcomes.
Area of Science:
- Hepatology
- Pathology
- Internal Medicine
Context:
- Liver cirrhosis was historically viewed as an irreversible condition, particularly in its decompensated stage.
- Progression to decompensation made returning to a compensated state extremely challenging.
Purpose:
- To review current research on liver cirrhosis reversal and recompensation.
- To explore advancements in understanding liver histopathology, function, and clinical complications in cirrhosis.
Summary:
- Emerging evidence suggests that decompensated liver cirrhosis can be reversed.
- Recompensation is achievable by addressing the underlying cause and managing associated complications.
- Research progress is examined across liver histopathology, liver function, and clinical manifestations.
Impact:
- Challenges the long-held belief of cirrhosis irreversibility.
- Offers hope for improved patient outcomes through targeted interventions.
- Provides a comprehensive overview of current research for clinicians and researchers.
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