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Task-residual effective connectivity of motor network in transient ischemic attack
Truc Chu1,2, Seonjin Lee1,2, Il-Young Jung3
1Research Center for Bioconvergence Analysis, Korea Basic Science Institute, Cheongju, 28119, Republic of Korea.
Communications Biology
|August 14, 2023
Summary
Transient ischemic attack (TIA) patients exhibit altered brain connectivity during motor tasks. These changes in effective connectivity may explain motor function deficits and voluntary movement control issues following TIA.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Transient ischemic attack (TIA) causes temporary neurological dysfunction due to focal brain ischemia.
- Despite symptom resolution, TIA patients face high stroke risk and lasting cognitive/motor impairments.
Purpose of the Study:
- Investigate alterations in effective brain connectivity in TIA patients during motor tasks.
- Utilize spectral dynamic causal modeling to analyze functional magnetic resonance imaging (fMRI) data.
Main Methods:
- Employed spectral dynamic causal modeling on 7T fMRI data.
- Compared 15 TIA patients with 28 healthy controls performing visually cued fist-closing movements.
Main Results:
- TIA patients showed increased effective connectivity to the ipsilateral primary motor cortex.
- Patients with TIA exhibited decreased effective connectivity to the supplementary motor area compared to controls.
Conclusions:
- TIA is associated with aberrant neural connections within motor regions.
- Altered connectivity may underlie reduced primary motor function efficiency and disrupted voluntary movement control in TIA patients.
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