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Non-coding RNAs as skin disease biomarkers, molecular signatures, and therapeutic targets
Andrea Roso-Mares1,2, Isabel Andújar3, Tania Díaz Corpas2,4
1Department of Dermatology, University of California San Diego, San Diego, CA, USA.
Abstract:
Non-coding RNAs (ncRNAs) are emerging as biomarkers, molecular signatures, and therapeutic tools and targets for diseases. In this review, we focus specifically on skin diseases to highlight how two classes of ncRNAs-microRNAs and long noncoding RNAs-are being used to diagnose medical conditions of unclear etiology, improve our ability to guide treatment response, and predict disease prognosis. Furthermore, we explore how ncRNAs are being used as both as drug targets and associated therapies have unique benefits, risks, and challenges to development, but offer a distinctive promise for improving patient care and outcomes.
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