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Mesomycoplasma ovipneumoniae from goats with respiratory infection: pathogenic characteristics, population structure,

Chunxia Ma1,2,3, Ming Li4, Hao Peng2,3

  • 1College of Animal Science and Technology, Guangxi University, Nanning, 530004, Guangxi, China.

BMC Microbiology
|August 14, 2023
PubMed
Abstract

Insights

This study reveals Mycoplasma ovipneumoniae strains cluster by geography and possess genes for adhesion and glycoside hydrolysis, aiding understanding of goat respiratory disease. This research provides a foundation for developing new treatments.

Area of Science:

  • Veterinary Microbiology
  • Genomics
  • Pathogenomics

Background:

  • Mycoplasma ovipneumoniae is a significant pathogen causing respiratory illness in goats, leading to considerable economic losses.
  • Understanding the genomic characteristics of M. ovipneumoniae is crucial for elucidating its disease-causing mechanisms.

Purpose of the Study:

  • To perform a genome-wide analysis of Mycoplasma ovipneumoniae strains.
  • To investigate the population structure and genomic features of M. ovipneumoniae.
  • To identify virulence factors and metabolic capabilities of M. ovipneumoniae.

Main Methods:

  • Whole-genome sequencing of nine M. ovipneumoniae strains from goats.
  • Epidemiological survey and toxicological pathology analysis.
  • Phylogenetic analysis and pan-genome analysis.

Main Results:

  • M. ovipneumoniae strains formed two distinct clades based on geographical origin.
  • The pan-genome analysis revealed 385 core genes and 5,001 accessory genes.
  • Identified genes associated with adhesion (cilium adhesion, surface adhesins) and extensive glycoside hydrolase activity; no antibiotic resistance genes were found.

Conclusions:

  • The identified population structure and genomic features are key to understanding M. ovipneumoniae pathogenesis.
  • This study provides a genomic basis for developing novel strategies against M. ovipneumoniae infections in goats.
Keywords:
Mycoplasma ovipneumoniaePan-genomePathogenesisWhole-genome sequencing

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