Related Experiment Video For Non-small cell lung cancer (NSCLC)
Updated: Jul 19, 2025
Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Can spectral computed tomography (CT) replace perfusion CT to assess the histological classification of non-small
Liangna Deng1,2,3,4, Jingjing Yang1,2,3,4, Tiezhu Ren1,2,3,4
1Second Clinical School, Lanzhou University, Lanzhou, China.
Background:
Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancer cases, it is necessary to distinguish the histological types of NSCLC. This study set out to investigate the correlation between spectral computed tomography (CT) and CT perfusion parameters in patients with NSCLC and to compare the differential diagnostic efficacy of these two imaging modalities for the histological classification of NSCLC.
Methods:
A total of 62 eligible consecutive patients, including 32 with lung adenocarcinoma (LUAD) and 30 with lung squamous cell carcinoma (LUSC), who underwent "one-stop" spectral combined perfusion scan and pathologically confirmed NSCLC at Lanzhou University Second Hospital between September 2020 and December 2021 were prospectively enrolled. The spectral parameters of lesions in the arterial phase (AP) and venous phase (VP) [including iodine concentration (IC), effective atomic number (Zeff), CT40keV, and slope of the spectral curve (K70keV)] and perfusion parameters [blood flow (BF), blood volume (BV), surface permeability (PS), and mean transit time (MTT)] were assessed. Pearson or Spearman correlation analysis was performed to evaluate the correlation between the two imaging parameters, and the DeLong test was used to compare the diagnostic performance of the two imaging modalities.
Results:
BV and BF were strongly correlated with spectral parameters CT40keV, IC, Zeff, and K70keV in the AP and VP (0.6
Conclusions:
Spectral parameters are significantly correlated with perfusion parameters in NSCLC, and spectral CT has a better diagnostic efficacy than perfusion CT in differentiating the histological classification of NSCLC.
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