Related Experiment Video

Updated: Jul 19, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.3K

Association between low-density lipoprotein cholesterol level and all-cause mortality in idiopathic dilated

Kexin Jiang1,2, Xiaobo Pu1, Yutong Liu3

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

Acta Cardiologica
|August 15, 2023
PubMed

Insights

In idiopathic cardiomyopathy (iDCM) patients, lower low-density lipoprotein cholesterol (LDL-C) levels are linked to increased mortality risk. This association is more pronounced in patients with poorer heart function, suggesting LDL-C

Area of Science:

  • Cardiology
  • Clinical Research
  • Epidemiology

Background:

  • Low-density lipoprotein cholesterol (LDL-C) is a known cardiovascular risk factor.
  • The prognostic role of LDL-C in idiopathic cardiomyopathy (iDCM) remains unclear.

Purpose of the Study:

  • To investigate the association between LDL-C levels and all-cause mortality in patients with iDCM.
  • To explore the predictive value of LDL-C for prognosis in iDCM.

Main Methods:

  • Retrospective study of 1058 iDCM patients.
  • Analysis of demographic data and variable correlations.
  • Cox proportional hazards models used to assess mortality risk.

Main Results:

  • Lower LDL-C levels (< 1.78 mmol/L) were associated with a 1.52-fold increased risk of all-cause mortality.
  • Higher LDL-C levels (> 2.28 mmol/L) correlated with better prognosis.
  • In patients with NYHA class III/IV, LDL-C showed a hazard ratio of 0.83.

Conclusions:

  • Lower LDL-C is an independent prognostic factor for increased all-cause mortality in iDCM.
  • The predictive value of LDL-C is stronger in patients with advanced heart failure.
  • LDL-C may serve as a potential biomarker for risk stratification in iDCM.
Abstract

Keywords:
Idiopathic dilated cardiomyopathyheart failurelow-density lipoprotein cholesterol

More Related Videos

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

4.6K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.5K

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
24
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
16
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
15
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
194