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Colloidal precipitates01:09

Colloidal precipitates

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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
622

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Development of silver nanoparticles based on the method using quince seed mucilage for ascorbic acid determination.

Nilay Beğiç1

  • 1Department of Analytical Chemistry, Faculty of Pharmacy, Biruni University, Istanbul, Turkey.

Phytochemical Analysis : PCA
|August 15, 2023
PubMed
Summary

A new green nanotechnology method uses quince seed mucilage (QSM) to create silver nanoparticles (SNPs) for simple, eco-friendly ascorbic acid determination in pharmaceuticals. This cost-effective approach offers high sensitivity for vitamin C analysis.

Keywords:
ascorbic acid determinationgreen nanotechnologypolysaccharidesquince seed mucilagesilver nanoparticles

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Area of Science:

  • Green Chemistry
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Nanoparticles offer enhanced sensitivity in detection across various scientific fields.
  • Green chemistry approaches for nanomaterial synthesis are gaining popularity.
  • Phytochemicals are increasingly utilized in nanoparticle synthesis.

Purpose of the Study:

  • To develop a novel green nanotechnology method for determining ascorbic acid in pharmaceutical preparations.
  • To utilize quince seed mucilage (QSM) as a bioreducing and stabilizing agent for silver nanoparticle (SNP) synthesis.
  • To establish a QSM-SNP-based assay for accurate ascorbic acid quantification.

Main Methods:

  • Silver(I) was reduced to silver(0) using QSM to form spherical, homogeneous QSM-stabilized silver nanoparticles (QSM-SNPs).
  • Ascorbic acid was quantified by measuring the enlargement of QSM-SNP nuclei via absorbance increase at 420 nm.
  • The method was validated for linearity, recovery, and precision.

Main Results:

  • The QSM-SNP method achieved a limit of detection of 0.27 μM and a limit of quantification of 0.90 μM for ascorbic acid.
  • The method was successfully applied to analyze ascorbic acid in effervescent tablets.
  • Common pharmaceutical excipients did not interfere with the assay.

Conclusions:

  • The developed QSM-SNP method aligns with green nanotechnology principles.
  • The method is characterized as simple, rapid, eco-friendly, and cost-effective.
  • This approach provides a viable analytical tool for pharmaceutical quality control.