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Reproductive Toxicity of Nanoparticles: A Comprehensive Review
Elaheh Mohammadi1,2, Behzad Behnam1,3,4,5, Ahad Mokhtarzadeh6
1Students Research Committee, Faculty of pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Current Medicinal Chemistry
|August 15, 2023
Summary
Nanoparticles (NPs) show unique properties but their reproductive toxicity is a concern. This review covers NP effects on sperm and ovum, including beneficial impacts and barrier passage.
Area of Science:
- Nanotechnology
- Reproductive Toxicology
- Biomedical Research
Background:
- Nanoparticles (NPs) possess unique properties driving diverse research applications.
- The safety profile of NPs, particularly concerning reproductive health, requires thorough investigation.
- Potential impacts of NPs on animal and human reproductive systems are a significant area of concern.
Purpose of the Study:
- To review the potential reproductive toxicity of various nanoparticles (NPs).
- To explore beneficial effects of NPs on the reproductive system.
- To analyze NP interactions with sperm, ovum, and reproductive barriers.
Main Methods:
- Literature review of studies on nanoparticle reproductive toxicity.
- Categorization of NPs including carbon nanomaterials, dendrimers, quantum dots, silica, gold, and magnetic NPs.
- Analysis of NP passage through blood-testis and placental barriers.
Main Results:
- Various NPs demonstrate potential reproductive toxicity.
- Some NPs have shown beneficial effects on reproductive parameters.
- NP accumulation in reproductive organs and effects on gametes are documented.
Conclusions:
- Understanding NP reproductive toxicity is crucial for safe application.
- Further research is needed to elucidate mechanisms of NP reproductive effects.
- The dual nature of NP effects (toxic and beneficial) warrants careful consideration.
