PET FDG CT is useful for giant-cell arteritis with isolated cough

Giant cell arteritis (GCA) is a chronic vasculitis of large- and medium-sized vessels. The most frequent symptoms are temporal headaches, scalp tenderness, jaw claudication and polymyalgia rheumatica in 35% of patients. Atypical presentation with dry cough is very rare and could be isolated making the diagnosis difficult. Initial imaging including PET-CT could be helpful. Literature review yielded 13 case reports with available data and one case series which focused on cough and which were all be included in this study. Most of the cases included males (n = 8), with mostly isolated cough or associated to fever and weight loss. Angio-CT of aortic wall was mostly normal, whereas FDG PET-CT showed in all available cases abnormal arterial thoracic uptake. Temporal artery biopsy was almost suggestive of GCA in all available cases. Cough was steroid responsive usually within few days in all cases without any need of combined therapy. Giant cell arteritis is the most common large-vessel vasculitis over the age of 50 in western countries. Isolated dry cough is extremely rare and encountered in less than 5% of cases.