Mouse phenome database: curated data repository with interactive multi-population and multi-trait analyses.

Area of Science:

• Genomics and Bioinformatics
• Translational Medicine
• Mammalian Genetics

Background:

• The Mouse Phenome Database (MPD) is a vital resource for researchers studying mouse models.
• It houses extensive phenotypic data across various mouse strains and populations.
• Accurate and accessible data is crucial for understanding genotype-phenotype relationships.

Approach:

• The MPD integrates community standard ontologies and guidelines for data annotation.
• It maintains a comprehensive database of allelic states for 657 mouse strains.
• The platform supports flexible, user-directed analyses integrating data across traits and populations.

Key Points:

• The database has expanded to include diverse mouse populations like Diversity Outbred, Collaborative Cross, and Hybrid Mouse Diversity Panel.
• It now incorporates data from the International Mouse Phenotyping Consortium.
• Data is accessible via API and an interactive tool suite for advanced analyses.

Conclusions:

• The MPD provides a flexible environment for exploring the genetic basis of phenotypic variation.
• Users can perform multi-population meta-analysis, outlier detection, and correlation analyses.
• This resource aids in understanding health and disease across the lifespan in mouse models.