Related Experiment Video

Updated: Jul 19, 2025

On-Chip Endothelial Inflammatory Phenotyping
12:43

On-Chip Endothelial Inflammatory Phenotyping

Published on: July 21, 2012

11.0K

The genesis of cardiovascular risk in inflammatory arthritis: insights into glycocalyx shedding, endothelial

Alexander Krasimirov Angelov1,2, Miroslav Markov3,4, Mariana Ivanova1,2

  • 1Medical Faculty, Medical University - Sofia, Sofia, 1431, Bulgaria.

Clinical Rheumatology
|August 15, 2023
PubMed

Insights

Inflammatory arthritis (IA) accelerates cardiovascular disease (CVD) by promoting atherosclerosis and endothelial dysfunction. The endothelial glycocalyx (EG) plays a key role in this process, highlighting the link between systemic inflammation and heart health.

Area of Science:

  • Cardiovascular Pathology
  • Rheumatology
  • Immunology

Background:

  • Inflammatory arthritis (IA) induces systemic inflammation beyond localized joint issues.
  • Chronic inflammation in IA significantly accelerates cardiovascular disease (CVD) progression.
  • The endothelial glycocalyx (EG) is implicated in early atherosclerosis development.

Purpose of the Study:

  • To comprehensively review the interplay between IA and cardiovascular pathology.
  • To elucidate the role of the endothelial glycocalyx (EG) in IA-driven CVD acceleration.
  • To explore mechanisms linking inflammation, EG degradation, and endothelial dysfunction.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of inflammatory mediators' impact on endothelial function and EG.
  • Examination of microparticles, microRNA, and complement activation in CVD pathogenesis.

Main Results:

  • IA exacerbates atherosclerosis initiation and endothelial dysfunction.
  • Inflammatory mediators modulate microtubule dynamics, affecting EG integrity.
  • Systemic inflammation and sheddases contribute to EG degradation, impacting CVD.

Conclusions:

  • IA significantly accelerates CVD through systemic inflammation and EG damage.
  • EG integrity is crucial for maintaining endothelial function in the context of IA.
  • Understanding these mechanisms offers insights into preventing IA-related cardiovascular events.

Keywords:
ArthritisAtherosclerosisBiomarkersGlycocalyxHeart disease risk factors

More Related Videos

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.2K
Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly00:06

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.4K

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
10
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12
Inflammation01:38

Inflammation

Overview
53.9K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.3K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16